The many faces of celiac disease

Article Abstract:

The malabsorption observed in celiac disease may be related to abdominal bleeding. Celiac disease is the inability to metabolize wheat gluten, a cause of diarrhea, weight loss, and some nutritional deficiencies. Consequent folate or iron deficiencies may cause anemia. A 1996 study found blood in the stool of a number of patients with celiac disease, possibly from damaged tissue in the mucosal lining of the intestines. Such blood loss may contribute to iron deficiency and anemia in patients with celiac disease. Interpretation of these results is limited, however, because stool may contain blood after eating certain foods, a condition that was not controlled in this study. Further research should be able to confirm the nature of fecal blood in celiac disease, thereby establishing it as an inflammatory disease of the intestinal system.

Editorial

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The prevalence of occult gastrointestinal bleeding in celiac sprue

Article Abstract:

Patients with celiac sprue may have frequent gastrointestinal bleeding, a factor possibly contributing to the iron deficiency found in this metabolic disorder. Celiac sprue is the inability to metabolize wheat gluten, often characterized by weight loss, nutritional deficiencies, and diarrhea. Guaiac-impregnated cards were used to test stool for blood samples at 48 hours and 72 hours. Researchers found blood in the stool of 47% of 36 patients with celiac disease, whereas only 6% of the 128 healthy people and other patients (the control groups) had evidence of occult blood in feces. Mucosal inflammation in the small intestines may be the source of this type of bleeding, although no direct evidence is available. The diagnostic value of this test for the detection of gastrointestinal cancer is questionable, however.

Health aspects, Diagnosis, Testing, Occult blood, Fecal occult blood test, Iron deficiency anemia

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Celiac disease -- the villain unmasked?

Article Abstract:

A 33-amino acid peptide that survives digestion in the stomach may be the cause of celiac disease. When the peptide reaches the small intestine, it triggers an autoimmune response. Celiac disease is a malabsorption syndrome triggered by gluten, a protein that occurs in many grains.

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