Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

Article Abstract:

Results point out that in the therapeutic effect of interleukin-2 depends on the timing of its administration and the differentiation status of the T cell. Data indicate that while administration during T cell expansion phase is detrimental, treatment is beneficial during the death phase, which leads to an increased proliferation and survival of virus-specific T cells.

United States, Drug therapy, Cellular control mechanisms, Cell regulation, T cells, Cell proliferation, Interleukin-2

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Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses

Article Abstract:

The article discusses the impact of targeting the glycoprotein D (gD) or an antigen to the herpesvirus entry mediator (HVEM) on the primary adaptive immune responses. It is clearly shown that targeting of antigen to HVEM increases the immunogenicity of the vaccines.

Science & research, Research, Glycoproteins, Control, Herpesviruses, Immune response, Antigens

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Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

Article Abstract:

Researchers have developed a mouse model of virus-induced respiratory failure and show that blocking lymphotoxin reverses the condition. This may allow researchers to develop a treatment for hantavirus cardiopulmonary syndrome.

Prevention, Septic shock, Tumor necrosis factor, Respiratory insufficiency

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