The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
Article Abstract:
The molecular adapter Grb-2 associated binder-2 (Gab2) associates with receptor activator of NF-kB (RANK) and mediates RANK-induced activation of NF-KappaB, Akt and Jnk is reported. A new, key regulatory scaffold molecule, Gab2, that controls select RANK signaling pathways is identified and is found to be essential for osteoclastogenesis and bone homeostatis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
Article Abstract:
Angiotensin-converting enzyme 2 (ACE2) is useful for protection against lung injury caused by severe acute respiratory syndrome coronavirus (SARS-CoV). The conversion of angiotensin II to angiotensin 1-7 by ACE2 reduces angiotensin II binding to the cell membrane receptors angiotensin II type 1a receptor (AT1aR) and angiotensin II type 2 receptor (AT2R).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
Article Abstract:
Researchers have shown that the novel E3 ubiquitin ligase HACE1 is downregulated in human tumors and is mapped to a region of chromosome 6q21 implicated in multiple human cancers. The studies have shown that HCAE1 is a candidate chromosome 6q21 tumor-suppressor gene that is involved in multiple cancers.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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