A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery

Article Abstract:

Low-dose heparin and intermittent pneumatic calf compression may be effective methods for preventing deep-vein thrombosis, or blood clot formation, after surgery for gynecological cancer. Intermittent pneumatic calf compression involves applying external pressure to prevent blood clot formation. Among 208 women who had surgery for different types of gynecological cancer, 107 were treated with low-dose heparin and 101 were treated with intermittent pneumatic calf compression. Seven patients treated with low-dose heparin developed deep-vein thrombosis, compared to four treated with intermittent pneumatic calf compression. Patients in the heparin group required more blood transfusions after surgery than those in the other treatment group. Treatment with heparin increases the risk of post-operative bleeding complications.

Health aspects, Women, Surgery, Drug therapy, Diseases, Cancer, Thrombosis, Deep vein, Deep vein thrombosis, Heparin

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Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer

Article Abstract:

Differences in tumor-cell characteristics may partially explain differences in survival rates between black and white patients with cancer of the uterine lining. Researchers evaluated characteristics of cancer cells in 117 white and 44 black women with early endometrial cancer. One-third of black women versus 11% of white women had overexpression of the p53 tumor suppressor gene, a factor associated with poor prognosis. Cancer recurred in 18% of women with tumors with this characteristic versus 9% of women whose tumors did not have this characteristic. Overall, 14% of black women had recurrent cancer versus 8% of white women.

Analysis, Demographic aspects, Health, Endometrial cancer, Gene expression, Health and race, Ethnic groups

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