The prognostic value of plasma viremia in HIV-infected patients under AZT treatment: a two-year follow-up study
Article Abstract:
Measurements of HIV particles in blood plasma may correlate with disease progression in HIV-infected people who are being treated with AZT. Researchers obtained several measurements of HIV particles in plasma from 28 HIV-infected patients who were receiving AZT therapy. Patients were followed up for an average of 21 months. Although AZT lowered HIV plasma levels, the reduction did not last in 13 (46%) of the 28 patients who experienced progression of their HIV disease. The 15 patients whose disease did not progress experienced stable levels of HIV in plasma after the decrease. An increase of HIV in plasma may happen before a decrease in CD4 cell counts is seen. HIV patients receiving AZT whose disease progresses may need to receive other therapies to halt this progression.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study
Article Abstract:
The level of HIV in cerebrospinal fluid (CSF) may rise during the course of infection in HIV patients not receiving antiretroviral medication. Researchers measured viral load and immune activity in 15 HIV-infected patients for 20 to 68 months. The level of virus in CSF rose significantly as infection progressed, and higher viral levels were associated with increased levels of neopterin, a marker of immune activity. No similar rise in viral load or neopterin was detected in blood samples. Persistent CSF infection may be related to the development of AIDS dementia.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Correlation between plasma HIV-1 RNA levels and the rate of immunologic decline
Article Abstract:
Blood levels of HIV RNA appear to be a good predictor of the decline of immune function in HIV-infected patients. Researchers periodically measured viral load in the form of HIV RNA and p24 antigen levels and also CD4+ T cell levels in 20 HIV-infected patients over an average of 10.8 months. In many of the patients, as HIV RNA levels increased, CD4+ T cell levels dropped. Patients with the highest HIV RNA levels had the worst prognosis. Blood levels of p24 antigen were not significantly associated with T cell decline.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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