The relationship of bone and blood lead to hypertension: the Normative Aging Study
Article Abstract:
Elevated levels of lead in bone tissue may be associated with an increased risk of hypertension. Lead levels in the bone, as opposed to levels in the blood, are thought to more accurately reflect long-term accumulation of blood lead in the body. Researchers analyzed blood pressure, and bone and blood levels of lead in 1,171 people. People with hypertension had bone and blood levels significantly higher than people without hypertension. Among those with hypertension, average levels of lead were 0.33 micromoles per liter in the blood, and 23.7 micrograms per gram of bone in the shin. Among people without hypertension, lead levels were 0.29 micromoles per liter in the blood, and 20.9 micrograms per gram of bone in the shin. Statistical analysis showed that important factors contributing to the risk of hypertension were family history of hypertension, body mass index, and lead levels in the shin bone.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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A longitudinal study of low-level lead exposure and impairment of renal function: the Normative Aging Study
Article Abstract:
Exposure to low levels of lead may adversely affect kidney function in men who are middle-aged and older. Researchers analyzed blood samples from 459 men aged 38 to 88 years, measuring levels of lead and the waste product creatinine, which is removed from the blood by the kidneys. At the beginning of the study the average blood levels of lead was 0.48 micromoles per liter and the average creatinine levels was 107 micromoles per liter. Blood levels of lead were directly related to creatinine levels over time. Multiplying the lead level by 10 predicted an increase in creatinine by 7 micromoles per liter. Levels of creatinine, which naturally increase with age, increased at a faster rate and began increasing earlier in men who were exposed to more lead.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Accumulated lead exposure an risk of age-related cataract in men
Article Abstract:
The study aims to determine the relationship of cumulative lead exposure with the development of cataract. It concluded that reduction of lead exposure could help decrease the global burden of cataract.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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