The risk of cancer among patients with cystic fibrosis

Article Abstract:

The incidence of digestive tract cancers may be higher than for other cancers in cystic fibrosis patients, many of whom are living to adulthood because of improved care. A retrospective study of 28,511 cystic fibrosis (CF) patients in North America from 1985 to 1992 and 18,000 in Europe revealed evidence of a high proportion of digestive tract cancers and a normal risk of other cancers. Many of the CF patients were only in their 20s at the time of cancer diagnosis. Of the 76 cancers detected in the over 46,000 CF patients, 24 involved digestive tract tumors. The CF disease process is known to affect the digestive tract. High levels of the cystic fibrosis transmembrane conductance regulator (CFTR) gene are found in digestive tissues. CF-induced changes in digestive tract organs may cause increased cell turnover, which in turn may explain the increased risk of digestive tract cancer. CF patients with gastrointestinal problems may need to be carefully examined for the presence of digestive tract tumors, although such a diagnosis may be uncommon.

Cancer, Cystic fibrosis

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Chronic pancreatitis and pancreatic cancer

Article Abstract:

Patients with chronic pancreatitis may have a higher risk of developing pancreatic cancer than other individuals. Pancreatic cancer is one of the most common types of cancer, and most patients with the disease die within one year of diagnosis. Risk factors for pancreatic cancer are unknown. The incidence of pancreatic cancer is higher among men than among women and among blacks than among whites. Different risk factors that have been examined include cigarette smoking, alcohol consumption, dietary factors and exposure to DDT. A research study found that patients with chronic pancreatitis may have a higher risk of pancreatic cancer. This study may have had certain biases that influenced its findings. The study began in 1946 before it was possible to distinguish between chronic pancreatitis and pancreatic cancer. Patients with chronic pancreatitis may be more likely to be diagnosed with pancreatic cancer because they are followed more closely.

Editorial

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Pancreatitis and the risk of pancreatic cancer

Article Abstract:

Patients with chronic pancreatitis may have a higher risk of developing pancreatic cancer than other individuals. Pancreatitis is an inflammation of the pancreas. Of 2,015 patients with chronic pancreatitis, 56 developed pancreatic cancer over an average of seven years. Only 2 cases of pancreatic cancer would be expected over the same period of time. Among patients who were followed over at least a two-year period, the risk of developing pancreatic cancer increased steadily. The risk was almost 2% 10 years after diagnosis of pancreatitis, and 4% 20 years after diagnosis. Patients with alcoholic pancreatitis did not have a higher risk of developing pancreatic cancer than those with non-alcoholic pancreatitis.

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