The rocky road to an AIDS vaccine

Article Abstract:

There are several obstacles to the development of a vaccine for HIV. The virus has many different strains, and one vaccine will not be able to protect against all strains. The results of scientific studies on a vaccine for one strain may not apply to other strains. The U.S. advisory committee overseeing the development of an HIV vaccine decided in June 1994 to postpone large scientific trials involving human subjects because the task was becoming very complex. In the meantime, the National Institutes of Health designated several locations in the U.S. with large groups of human volunteers in which future large trials can be conducted. Researchers will need to protect volunteers against discrimination from being associated with the trial, as this could hamper efforts to develop a vaccine.

Editorial

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Binding analysis of 95 HIV gp120 peptides to HLA-DR1101 and -DR0401 evidenced many HLA-Class II binding regions on gp120 and suggested several promiscuous regions

Article Abstract:

Many parts of the HIV gp120 protein appear capable of binding to HLA Class II molecules. Researchers chemically synthesized 95 peptides from the gp120 protein and tested their ability to bind to two HLA Class II molecules, DR1101 and DR0401. These two molecules differ enough in sequence to represent distinct molecules. Thirty-five of the peptides bound to both molecules and 56 bound to one or the other. Since T cells only bind to foreign proteins that are bound to HLA antigens, this means that an AIDS vaccine that contains these 56 peptides would be effective in raising an immune response in most people.

Testing, Physiological aspects, Protein binding, HLA class II antigens

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HIV-1 risk and vaccine acceptability in the Ugandan military

Article Abstract:

AIDS vaccines might be effectively tested in members of the Ugandan military. About 18% of military members are infected with HIV. Among non-infected soldiers, 88% reported an interest in receiving an HIV vaccine, which they believed would be more reliable than condoms or monogamy in preventing HIV infection.

Uganda, Statistical Data Included, HIV infection, HIV infections, Soldiers

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