The role of fetal karyotyping from unconventional sources

Article Abstract:

Fetal fluid specimens other than amniotic fluid may be successfully used for chromosomal analysis. This may avoid a second invasive procedure or permit genetic counselling when the fetus subsequently dies. Researchers cultured and analyzed 39 fetal fluid samples drawn during diagnostic or treatment procedures from the lungs, abdomen, around the heart, cysts, or from urine samples. They compared results with amniotic fluid samples. Thirty-four samples were successfully cultured and analyzed. In all but one case, the chromosomal profiles agreed. That instance was believed to be a mosaic, a case where not all cells are identical.

Karyotypes, Body fluids

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Fetal origin of amniotic fluid polymorphonuclear leukocytes

Article Abstract:

Inflammatory cells found in amniotic fluid of pregnant women with intrauterine infection may be from the fetus rather than the mother. Researchers analyzed the origin of inflammatory cells in amniotic fluid from four women delivered prematurely of male fetuses because of intrauterine infection. Fluorescence in situ hybridization revealed that over 90% of the inflammatory cells contained both an X and a Y chromosome, indicating that they were from the male fetus. The presence of fetal cells in fluid from an infected uterus reveals that the fetus responds to infection even when membranes are intact.

Maternal-fetal exchange, Genetic aspects, Leukocytes, White blood cells, Chorioamnionitis

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Influence of gestational age on fetal deoxyribonucleic acid retrieval in maternal peripheral blood

Article Abstract:

Fetal cells may be most prominent in the blood of pregnant women during the first trimester. Fetal cells enter maternal circulation in very small numbers, and may provide genetic material that could be used in noninvasive prenatal fetal testing. Researchers collected blood samples during each trimester from 27 pregnant women. Detection of fetal DNA from male fetuses was less effective in the second trimester, perhaps because the concentration of fetal cells in maternal blood falls during the middle of pregnancy.

Gestational age, Prenatal diagnosis

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