The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study

Article Abstract:

Infants of pregnant women who take calcium channel blockers in the first trimester may not have an increased risk of birth defects. Researchers analyzed data from six medical centers that collected data on pregnant women's exposure to calcium channel blockers. Seventy-eight women with such exposure were followed up, and no increase in major birth defects was found. Two malformed infants were found in the group, but their mothers had serious health conditions and were taking other drugs as well. Women who took calcium channel blockers experienced a slightly lower rate of live births. Pregnant women who take calcium channel blockers in the first trimester should receive prenatal counseling that reassures them of the low risk of birth defects. The results of animal studies of drug exposure may not always apply to humans.

Birth defects, Calcium channel blockers

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MgS[O.sub.4] prevents left ventricular dysfunction in an animal model of preeclampsia

Article Abstract:

Study is presented to hypothesize that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor and be reversed with magnesium sulfate prophylaxis. Results show that cardiac function is depressed in an animal model of preeclampsia induced by L-NAME infusion. MgS[O.sub.4] prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia.

Care and treatment, Heart diseases

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Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia

Article Abstract:

A study was conducted to check if the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects. Results indicated that the use of nifedipine and magnesium sulfate together does not increase the risk of serious magnesium-related effects.

United States, Drug therapy, Dosage and administration, Nifedipine

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