Thiazide diuretics and the risk of hip fracture
Article Abstract:
Fracture of the hip in older people is a costly, painful, debilitating occurrence, and individuals with reduced bone mass are particularly at risk. It has been suggested that one class of drugs commonly prescribed for treating high blood pressure, the thiazide diuretics, improve bone mass and decrease the risk for hip fracture, but additional data concerning this issue are needed. To this end, relevant data were analyzed from the Framingham Heart Study, a long-term study of cardiovascular disease risk factors. The cases of 176 women who had suffered hip fracture were compared with 672 age-matched controls to determine the effects of thiazide diuretics. Users were categorized as having used any form of thiazide (pure thiazide or thiazide-containing pills); pure thiazide (no combination pills); or combination pills only. Drug use was further categorized as recent, past, or ever, referring to use during different periods relative to the study interval when the fracture occurred. Results showed that compared with controls, cases were thinner, drank more caffeine, took less estrogen hormone replacement therapy, and had poorer vision. Although thiazide users, in general, had a decreased risk of fracture compared with nonusers, statistically significant differences were only found for women who had taken pure thiazides recently. Such agents contain higher thiazide doses than combination drugs. Women with a history of thiazide use who had stopped taking the drug were not protected against hip fracture; in fact, their risk was increased. A discussion is presented of therapeutic considerations associated with high doses of thiazides, which can cause toxic side effects. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1991
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Large-scale analysis of associating between LRP5 and LRP6 variants and osteoporosis
Article Abstract:
A study to examine whether mutations to low-density lipoprotein receptor-related protein 5 (LRP5) and LRP6 affected bone mineral density (BMD) and increased the risk of fractures was conducted. Results revealed that LRP5 variants were commonly associated with BMD and increased risk of fractures.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2008
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Efficacy of a hip protector to prevent hip fracture in nursing home residents
Article Abstract:
A clinical trial which was conducted to determine if an energy-absorbing/dispersing hip protector could reduce the risk of hip fracture when worn by patients was unable to prevent hip fracture among nursing home residents.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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