Thromboxane biosynthesis and platelet function in type II diabetes mellitus
Article Abstract:
Thromboxane, a substance that plays a role in the natural clotting process, has been shown to be produced in higher quantities by platelets from diabetic patients, as well as by platelets from diabetic laboratory rats. However, it is not known if these results, which were obtained in tissue culture experiments, represent the conditions within the body. To determine if a comparable increased production of thromboxane occurs in patients with non-insulin-dependent diabetes, the excretion of thromboxane metabolites was measured in 50 diabetic patients and in 32 healthy controls. The diabetic patients had normal kidney function and evidence of blood vessel disease, possibly indicative of clotting problems. The results showed clear evidence of increased excretion of thromboxane metabolites in the diabetic patients. However, this does not mean that the synthesis of thromboxane is increased unless it can also be shown that the breakdown of thromboxane is essentially normal in these patients. This was established by injecting the experimental subjects with additional thromboxane B2. The breakdown of this additional thromboxane was monitored by measuring 11-dehydro-thromboxane B2, a normal metabolite, in the urine. The course of the breakdown was the same in the patients and the healthy controls. These results indicate that thromboxane production, which most likely involves platelets, is increased in patients with type II diabetes. This increase can be moderated somewhat by careful metabolic control of the diabetes and with the use of low-dose aspirin. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1990
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A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
Article Abstract:
Myocardial Infraction and a therothrombotic ishemic stroke are considered to be caused by the rupture of vulnerable atherosclerotic plaques, which are complex disorders that result from multifaceted interactions between an individual's genetic makeup and environmental factors.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
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A polymorphism n the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
Article Abstract:
Myocardial Infraction and a therothrombotic ishemic stroke are considered to be caused by the rupture of vulnerable atherosclerotic plaques, which are complex disorders that result from multifaceted interactions between an individual's genetic makeup and environmental factors.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
User Contributions:
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