Thyroid gland: US in patients with Hodgkin disease treated with radiation therapy in childhood
Article Abstract:
The association between the development of both benign and cancerous tumors of the thyroid after receiving relatively low-level radiation therapy of the neck during childhood is well known and documented. Less studied, however, is the effect on the thyroid gland of receiving high-dose radiation therapy. Patients with a form of lymphatic cancer, Hodgkin disease, are often treated with relatively high doses of radiation during childhood. A review of the treatment records of 30 Hodgkin patients investigates the correlation of such radiotherapy and the ultrasonic detection of abnormalities of the thyroid. In this group 24 patients were found with abnormalities of the thyroid on ultrasound (US) examination. At the time of obtaining abnormal thyroid results by US, 17 of these patients did not have abnormalities of thyroid function tests (blood tests which assess thyroid function). US appears to be a highly sensitive measure of radiation therapy damage. The risk of such pathologies developing was greater with increased time from treatment and indicates that physicians should be aware of the need for continued long-term surveillance of Hodgkin patients who have received radiation to the upper body.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1989
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Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression
Article Abstract:
An experiment done to determine the clinical effects of Multi Colony Stimulating Factor (Multi-CSF) seems to contraindicate its use in accelerating hematopoietic regeneration after marrow transplantation. Multi-CSF stimulates many different cell types in the bone marrow and causes the levels of Multi-CSF circulating in the blood to rise. In the experiment mouse bone marrow cells were genetically changed and transplanted into mice. As a result, extremely high levels of Multi-CSF were found in the blood and various organs of the m;ice while the white blood cell count of the bone marrow decreased by half. Primitive or immature white blood cells were found in high concentration in the spleen. Most of the mice transplanted with the cells died within 5 weeks and had massive white blood cell infiltration of their spleen, liver, muscle, skin and intestines.
Publication Name: Blood
Subject: Health
ISSN: 0006-4971
Year: 1989
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