Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross priming
Article Abstract:
The role of exosomes in the transfer of tumor antigens to dendritic cells in human in vitro model systems are examined. Topics include the implications exosomes have for T-cel cross priming as it relates to immunological interventions.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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A novel dendritic cell subset involved in tumor immunosurveillance
Article Abstract:
The identification of interferon-producing killer dendritic cells (IKDCs) as pivotal sensors and effectors of the innate antitumor immune response is discussed. Tumor outgrowth can be prevented by the adoptive transfer of IKDCs into tumor-bearing Rag2-II2rg mice.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Article Abstract:
A previously unrecognized pathway is described in both mice and humans for the activation of tumor antigen-specific T-cell immunity that has involved secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs). The results have delineated a clinically relevant immunoadjuvant pathway triggered by tumor cell death.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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