Transport of immunoglobulin G and its subclasses across the in vitro-perfused human placenta
Article Abstract:
Commercial preparations of immunoglobulin G (IgG) may cross through the human placenta from mother to fetus and provide some protection to the fetus against blood disease. IgG is a natural antibody that is given intravenously to pregnant women with a disease that causes low blood platelet counts. Researchers used newly delivered human placentas to analyze the flow of IgG from the mother's side of the placenta to the fetal side. A low concentration of IgG became present on the fetal side two hours after it was administered on the mother's side, but it increased after five hours. The slow transfer rate of IgG from mother to fetus suggests that mothers with certain blood diseases should receive IgG a few weeks before delivery to ensure that the fetus receives the full benefit of IgG.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Quantitative immunophenotypic characterization, cryopreservation, and enrichment of second- and third-trimester human fetal cord blood hematopoietic stem cells (progenitor cells)
Article Abstract:
Umbilical cord blood from second- and third-trimester fetuses contains more CD34+ and CD34+CD38- cells than cord blood from fetuses at the full term of gestation. Researchers compared 31 umbilical cord blood samples for the quantity and characteristics of hematopoietic stem cells, the precursors of all blood cells. Cold preservation and enrichment of blood samples were successful at all stages of gestation, but blood collected earlier in pregnancy was richer in stem cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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