Treatment of cytomegalovirus retinitis with intravitreous cidofovir in patients with AIDS: a preliminary report
Article Abstract:
Cidofovir injections directly into the eye appear to be effective in treating cytomegalovirus infections in the eyes of patients with AIDS. Every five to six weeks doctors injected cidofovir into 32 infected eyes of 22 patients with AIDS. There was no disease progression in the 15 eyes that received cidofovir injections as the first and only cytomegalovirus infection treatment and in all but two of the eyes that had received previous treatment. Treatable iris inflammation occurred in more infected patients previously treated with probenecid than in those not previously treated.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial
Article Abstract:
Both high and low concentrations of cidofovir treatment appear to be effective in delaying eye complications seen in patients with AIDS and untreated cytomegalovirus (CMV) associated retinitis. Sixty-four patients with CMV-associated retinitis were treated either immediately with a low or high dose of cidofovir or after retinitis had progressed. Low-dose cidofovir delayed retinitis progression from 21 days as seen in the delayed treatment group to 64 days. Half of the group treated with high-dose cidofovir did not progress to CMV-associated retinitis by the study's end.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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Clinical experience with cidofovir in the treatment of cytomegalovirus retinitis
Article Abstract:
Cidofovir (Vistide) is a newly developed nucleotide analog to treat cytomegalovirus retinitis. Cytomegalovirus retinitis is an infection of the retina caused by cytomegalovirus. Two clinical trials have shown that cidofovir is effective in treating cytomegalovirus retinitis, especially in patients who are resistant to other drugs. Cidofovir can be administered intravenously twice a month and does not require indwelling catheters. However, the drug can damage the kidneys, and so it should be given along with probenecid and saline and the dose should not be exceeded.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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- Abstracts: Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. New therapies for cytomegalovirus retinitis
- Abstracts: Therapy for cytomegalovirus retinitis: still no silver lining. Better treatment for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome
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