Treatment of posterior hypospadias by the autologous graft of cultured urethral epithelium
Article Abstract:
Hypospadias is a congenital abnormality in which the opening of the male urethra (penile opening) is located on the underside of the penis. This is caused by an improper fusion of embryologic components which together form the penis. Surgery to correct this defect has used tissues taken from other parts of the child's body, including the skin and the lining (epithelium) of the urinary bladder. A recent innovation in resurfacing the body following devastating burns and other wounds has been the growing of large sheets of skin cells in the laboratory using a technique known as tissue culture. In this method, a very small sample of the patient's skin is taken by biopsy and is grown into large sheets in a fluid which resembles tissue fluid. When a sufficient amount of tissue has been produced, usually within several weeks, the tissue is then used to repair the abnormality. This study utilized appropriate tissue samples taken from patients with hypospadias to prepare sheets of epithelium that could be used in their surgical repair. The method has now been used to surgically repair the abnormal urethra in two boys (aged 4 and 13 years old) with hypospadias; the technique was successful. The method is particularly beneficial because it eliminates the need to remove tissue from the bladder. The first patient received a two-part surgical repair, but that led to the development of a one-stage procedure that was used for the second patient. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1990
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Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium
Article Abstract:
Ocular trauma or disease may lead to severe corneal opacification and consequently severe loss of vision as a result of complete loss of corneal epithelial stem cells. Sutureless transplantation of carrier-free cell sheets composed of autologous oral mucosal epithelial cells could be used to reconstruct corneal surfaces and restore vision in patients with bilateral severe disorders of the ocular surface.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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Case 36-2004: A 23-Day-old infant with hypospadias and failure to thrive
Article Abstract:
A case study of a 23-day-old male infant is presented who was admitted to the hospital because of difficulty feeding and failure to thrive. An evaluation for sepsis was negative and an abdominal ultrasonographic study of the child showed mild left hydronephrosis.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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