Validity of reported pain as a measure of clinical state in juvenile rheumatoid arthritis

Article Abstract:

Juvenile rheumatoid arthritis is a long-term inflammatory disease affecting the entire body which may cause joint or connective tissue damage, and lesions of the abdominal organs. The disease develops before the age of 16 years, and complete remission occurs in 75 percent of patients. Although juvenile rheumatoid arthritis is associated with joint pain, it is not clear if pain serves as an indicator of disease activity. Joint pain is less severe in children than in adults with rheumatoid arthritis, and has not been correlated with disease activity and severity. Reported pain may reflect cognitive or intellectual development, and may be related to maturation. In one study, it was concluded that children between 12 and 17 years reported pain more often than younger children because of their better understanding of the disease. The usefulness of reported pain in juvenile rheumatoid arthritis in reflecting disease activity was assessed. Parent reports of children's pain for 101 children with juvenile rheumatoid arthritis were collected and differed by type of disease. The clinical state, consisting of joint activity, morning stiffness, and overall disease activity, influenced pain reporting by parents; pain reports were unrelated to age. These findings suggest that reported pain in juvenile rheumatoid arthritis may serve as an indicator of disease state. (Consumer Summary produced by Reliance Medical Information, Inc.)

Measurement, Joint diseases, Pain in children, Pediatric pain

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Serum p55 and p75 tumour necrosis factor receptors as markers of disease activity in juvenile chronic arthritis

Article Abstract:

Soluble tumor necrosis factor alpha receptor p55 and p75 (sTNFRp55, sTNFRp75) levels may be useful indicators of disease activity in patients with juvenile chronic arthritis (JCA). Researchers analyzed blood samples from 45 patients with JCA, joint fluid samples from 5 patients with JCA, and 20 blood samples from healthy volunteers (controls) for sTNFRp55, sTNFRp75, TNFa, and interleukin-6 (IL-6) levels. They compared these levels with their doctor's evaluation of disease activity. There were significant correlations between sTNFRp55 and sTNFRp75 levels and disease activity as reported by the doctors and as measured by C reactive protein levels and erythrocyte sedimentation rates. There was a trend towards increases in TNFa levels with disease activity but not significantly so. There was a greater concentration of sTNFRp55 and sTNFRp75 in the joint fluid samples as compared to the blood samples. sTNFRp75 levels were higher than sTNFRp55 levels.

Tumor necrosis factor

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Conspicuous synovial lymphatic capillaries in juvenile idiopathic arthritis synovitis with rice bodies

Article Abstract:

Morphological results on rice bodies in patients with juvenile idiopathic arthritis synovitis are examined.

Science & research, Slovakia, Research, Synovial fluid

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