Treatment of the Crigler-Najjar syndrome type 1 with hepatocyte transplantation

Article Abstract:

Transplantation of liver cells may be a promising treatment for Crigler-Najjar syndrome type 1. This disease is caused by a defect in the enzyme that metabolizes bilirubin, a chemical produced by the body. Researchers transplanted liver cells taken from a deceased boy into a 10-year-old girl with this disorder. About one month after the transplant, the level of bilirubin in her blood dropped to half its pre-transplant level. She also had enzyme activity and evidence that the bilirubin was being metabolized. Her transplanted cells lasted for more than 11 months.

Health aspects, Care and treatment, Liver, Liver transplantation, Hyperbilirubinemia

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

Article Abstract:

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may be too toxic to the liver to be used as chemotherapy in humans. Although it can induce apoptosis in cancer cells, it also caused massive death of normal human hepatocytes.

Cell death, Antineoplastic agents

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Converting hepatocytes to beta-cells -- a new approach for diabetes?

Article Abstract:

Transferring the homeobox gene PDX-1 into liver cells makes the cells produce insulin. Liver cells could be engineered to act like pancreatic beta cells, providing a source of insulin for diabetics.

Diabetes, Genetic engineering, Insulin, Diabetes research

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