Tuberous sclerosis and parathyroid adenoma

Article Abstract:

Tuberous sclerosis is an inherited disorder that is characterized by mental retardation, episodes of epilepsy, and development of sebaceous adenomas of the skin (tumors of glandular origin secreting fats or oils). Nodules or tubers that are hard because of the presence of calcium form in the brain. Hardened nodules are also found in various bones of the body, including bones of the skull, pelvis, fingers, and toes. Organs such as the kidneys, lungs and heart are also affected. Infrequently, glandular tissue can also be affected, including glands of the liver, pancreas, adrenal, pituitary, testes, ovaries and thyroid. A case study is presented of a 15-year-old boy who had tuberous sclerosis and parathyroid disease. Only one other similar case, where the two disorders were associated, has been previously reported. Upon examination, the boy was found to have inflammation of the pancreas, high levels of calcium in his blood, and increased parathyroid activity due to increased production of the parathyroid hormone. Parathyroid hormone regulates the level of calcium in the body, causing resorption of calcium from the bones. An adenoma was located in a parathyroid gland. The adenoma was removed surgically and the levels of calcium in the blood were subsequently reduced. It is felt that levels of calcium should be monitored in patients with tuberous sclerosis, as high levels of calcium due to an adenoma in the parathyroid gland may occur in these patients. (Consumer Summary produced by Reliance Medical Information, Inc.)

Complications and side effects, Calcium in the body, Calcium (Nutrient), Endocrine gland tumors, Tuberous sclerosis

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Middle ear adenoma: tumour of mixed mucinous and neuroendocrine differentiation

Article Abstract:

Middle ear adenomas, tumors of the middle ear, are very rare, but normally can be surgically removed without complications. The types of cells from which these tumors originate are not known. Two cases are presented of middle ear adenomas removed from patients with progressive hearing loss. Upon examination of tissue samples, the tumors were contained two types of glands, one secreting mucous (mucinous differentiation), and the other containing secretory granules typical of tissue involved in the stimulation of the nervous system (neuroendocrine differentiation). These cases demonstrate that middle ear adenomas can be tumors of mixed cell types, containing cells of mucinous and neuroendocrine differentiation. Knowledge of the origins of the tumors will add to the understanding of how these tumors grow and may help in the development of alterative methods of treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Pathological histology, Middle ear

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Gastric duplication in an adult mimicking mucinous cystadenoma of the pancreas

Article Abstract:

France, Evaluation, Risk factors, Cancer, Cysts, Pancreatic tumors, Carcinoma, Pancreatic tumours

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