Tumor necrosis factor blockers in rheumatoid arthritis
Article Abstract:
More research is needed before drugs that block tumor necrosis factor can be recommended for the treatment of rheumatoid arthritis. Tumor necrosis factor is an inflammatory protein produced by the body. Because rheumatoid arthritis is partly an inflammatory disease, drugs that inhibit tumor necrosis factor might be useful. A 2000 study shows that an inhibitory drug called etanercept is indeed beneficial in children with juvenile rheumatoid arthritis. The drug has also been tested in adults with similar benefits. However, it is more expensive than traditional arthritis drugs.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
Article Abstract:
The efficacy and safety of abatacept, a selective costimulation modulator, was assessed in patients with active rheumatoid arthritis and an insufficient response to a minimum of three months of anti tumor necrosis factor alpha (TNF-alpha) treatment. Findings confirmed that patients with insufficient response to anti-TNF-alpha treatment benefited substantially in both clinical and functional aspects.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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Tuberculosis associated witih inflximab, a tumor necrosis factor alpha-neutralizing agent
Article Abstract:
The drug Remicade may cause tuberculosis in patients who take the drug for rheumatoid arthritis or Crohn's disease. Remicade blocks the activity of tumor necrosis factor-alpha, which is an immune system protein. This supports the idea that tumor necrosis factor-alpha may protect people from tuberculosis.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
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