Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age
Article Abstract:
A normal ultrasound scan reduces the risk of women aged 35 or more carrying a baby with Down syndrome. Researchers calculated how much a normal ultrasound scan taken in the second trimester reduced the risk of Down syndrome in 4,079 women who had second-trimester ultrasound measurements and an amniocentesis. Amniocentesis revealed 40 cases of Down syndrome. The risk fell from 1 in 270 at age 35 to 1 in 787 with normal ultrasound, 1 in 210 to 1 in 612 at age 36, 1 in 165 to 1 in 481 at age 37, 1 in 130 to 1 in 379 at age 38, 1 in 100 to 1 in 292 at age 39, and 1 in 70 to 1 in 204 at age 40.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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An alternative for women initially declining genetic amniocentesis: individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Article Abstract:
Certain fetal measurements assessed by ultrasound combined with the pregnant woman's age can predict whether her infant is affected by Down syndrome. Researchers used ultrasound to measure various fetal body parts in 30 women known to carry a Down syndrome fetus and 3,254 women with healthy fetuses. A thick neck, short thigh bone, shortened little finger and intestinal abnormalities predicted the presence of a Down syndrome fetus, as did maternal age. This technique was as effective as the triple screen and could be used for women who do not want amniocentesis.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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Elevated maternal urine level of beta-core fragment of human chorionic gonadotropin versus serum triple test in the second-trimester detection of Down syndrome
Article Abstract:
Measuring the amount of beta-core fragment of human chorionic gonadotropin in a pregnant woman's urine appears to be as effective as the traditional triple test in detecting Down syndrome. The triple test measures alpha fetoprotein, chorionic gonadotropin and unconjugated estriol in blood samples.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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