Validation of genetic case-control studies in AIDS and application to the CX3CR1 polymorphism
Article Abstract:
More research on larger groups of patients is needed to determine whether the gene for the CX3CR1 HIV-1 receptor can confer resistance to HIV infection. This has been shown in some studies of long-term non-progressors.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
Article Abstract:
The relative contributions to AIDS progression of CCR2 641, CCR5 delta32, and CCR5 promoter haplotype +.P1.+ in the GRIV cohort, which included patients representing the extremes of the distribution for AIDS progression are reported. The comparison of subjects progressing in the first three years after HIV-1 infection with average progressors showed that CCR5 dellta32 and CCR5 P1 have a strong influence early in HIV-1 infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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Tat toxoid as a component of a preventive vaccine in seronegative subjects
Article Abstract:
A vaccine against the Tat protein of HIV may prevent the virus from destroying a patient's imune system. This protein is believed to cause the immunosuppression that is seen in HIV patients. Researchers vaccinated five HIV-negative people with an anti-Tat vaccine called Tat toxoid. All five people developed antibodies against Tat and also had an increased T cell response to the protein.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1999
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