Variables Influencing Penicillin Treatment Outcome in Streptococcal Tonsillopharyngitis

Article Abstract:

Several characteristics determine whether children with group A (beta)-hemolytic streptococcal (GABHS) tonsillopharyngitis can be successfully treated with penicillin. GABHS is a bacterial infection in the throat. During a 2.5-year study of 359 children treated for GABHS, 82% of the children who were treated two or more days after their diagnosis were successfully treated, compared to 64% of those who began treatment less than two days after diagnosis. Children six years old or older were more likely to be cured than those five or younger. Penicillin was effective whether given 2, 3, or 4 times a day.

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Incidence of Streptococcal Carriers in Private Pediatric Practice

Article Abstract:

Some children are carriers of group A (Beta) hemolytic streptococcus (GABHS) even though they have no symptoms of infection. In a study of child patients at one pediatric practice, 2.5% of well children tested positive as carriers of GABHS but had no symptoms. Of the children with a sore throat, 4% were carriers and of children who had a sore throat and a documented viral infection, 7% were carriers. Penicillin treatment for suspected bacterial respiratory infection was less effective in reducing the carrier rate than cephalosporins and macrolide antibiotics.

Statistics

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A study of 5-day cefdinir treatment for streptococcal pharyngitis in children

Article Abstract:

Five days of oral cefdinir treatment may be superior to 10 days of oral penicillin V in treating strep throat in children. Researchers randomly assigned 440 children aged 1 to 12 with positive throat tests for Streptococcus pyogenes to either cefnidir twice a day for 5 days or penicillin V four times a day for 10 days. Clinical cure rates were similar: 92% and 91%, respectively. However, Streptococcus pyogenes was eradicated in 90% of the cefdinir group but only 72% of the penicillin group. Minor side effects were equally common in both groups.

Cephalosporins

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