Vascular outcome in men with asymptomatic retinal cholesterol emboli: a cohort study
Article Abstract:
Cholesterol clots that lodge in the retinal blood vessels without producing symptoms may increase the risk of stroke by nearly 10 fold. Beginning in 1989, researchers followed 140 elderly people, 70 of whom had symptomless clots in the retinal blood vessels. After an average period of 3.4 years, strokes had occurred in 17 people with retinal clots and two people in the control group. None of the strokes caused death. Most strokes in the people with retinal clots occurred from obstructions in the carotid artery on the same side of the body as the retinal clot. Nonfatal heart attacks or death from atherosclerosis occurred in 17 people with retinal clots and in 12 of the controls. Twenty people with retinal clots and 15 in the control group died during the study period.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Whither recombinant human growth hormone?
Article Abstract:
Insulin-like growth factor 1 (IGF-1) and human growth hormone therapies seem to hold promise for certain patient populations but many questions remain unanswered. Recent studies have shown that body composition measurements improved with IGF-1 therapy in adults with growth hormone deficiencies. Hormone treatment studies in emaciated patients with AIDS have shown modest improvements in body composition measurements. Future studies need to address the cost effectiveness of $1000 per week hormone treatments and whether the improvements seen in preliminary studies only represent increases in water weight.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting: a randomized, double-blind, placebo-controlled trial
Article Abstract:
Combination therapy with insulin-like growth factor 1 (rhIGF-1) and recombinant human growth hormone (rhGH) appears to provide modest but short-lived weight gain in emaciated patients with AIDS. Sixty emaciated patients with AIDS were treated for 12 weeks with either rhIGF-1 alone, rhGH alone, a combination of the two hormones, or placebo. Patients taking any growth hormone therapy gained weight after six weeks. The weight gain effect lasted until 12 weeks only among those taking combination therapy. Quality of life and some muscle strength improved in those taking rhGH alone.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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