Vasoactive intestinal polypeptide loses its ability to increase vaginal blood flow after menopause
Article Abstract:
In women who are fertile and not pregnant, vasoactive intestinal polypeptide (VIP) increases vaginal blood flow and lubrication to levels observed during sexual arousal. The effects of VIP were investigated in postmenopausal women by studying six women (average age, 58) who took no medication and six women (aged 54) who took hormonal replacement therapy for menopausal symptoms. Vaginal blood flow was measured by a heated probe placed in the vagina before and after an intravenous infusion of VIP. Blood was sampled at regular intervals to determine VIP concentrations. Results showed that the drug did not increase vaginal blood flow for women who did not take hormones, but it did increase blood flow for women on hormone replacements. The women had similar increases in their blood VIP levels. It appears that the vaginal effects of VIP are dependent on the presence of sex hormones. Additional research is needed to characterize the physiological aspects of these mechanisms. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1991
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Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties
Article Abstract:
Cigarette smoke appears to affect the arteries in the placenta, which could reduce blood flow to the fetus. Smoking during pregnancy is a risk factor for low birth weight. Researchers measured several physiologic responses in the placental arteries of smokers and non-smokers. Placental arteries from smokers constricted more in the presence of vasoconstrictive chemicals than the arteries of non-smokers. Smokers' arteries had different mechanical properties than those of non-smokers.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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Risk factors among young women with endometrial cancer: a Danish case-control study
Article Abstract:
Risk factors for endometrial cancer include family history, age at first pregnancy, pregnancy outcome, and use of oral contraceptives. This was the conclusion of a study of 237 women with endometrial cancer and 538 healthy women.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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