Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
Article Abstract:
Anti-HIV drugs can still be useful even if the virus develops resistance to them. This was the conclusion of a study of 16 HIV patients, somie of whom discontinued the drugs. Although the virus became susceptible to the drugs again when the drugs were discontinued, CD4 T cell counts decreased and viral levels increased.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
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Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
Article Abstract:
Research presented concerns the relationship between HIV-1-mediated T-cell loss and lymphocyte development or increased thymic function. Findings suggest that a homeostatic response to T-cell loss is an increase in the production of interleukin-7.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
Article Abstract:
Research has been conducted on the recombinant HIV-1 clones that contain wild-type or the protease inhibitor-resistant protease domains. The study of these clones in the activated peripheral blood mononuclear cells and in human thymic organ cultures has been carried out and the results indicate that the wild-type and protease inhibitor-resistant HIV-1 isolates have replicated in peripheral blood mononuclear cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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