Viruses and microRNAs
Article Abstract:
The potential functions of the virally encoded microRNAs (miRNAs) identified in several pathogenic human viruses are highlighted. It is likely that cellular miRNAs may have a substantial effect on viral evolution and increasing knowledge of the role and importance of virally encoded miRNAs will probably offer new insights into how viruses that establish latent infections avoid elimination by the host innate or adaptive immune system and this knowledge can also be used to treat virally induced diseases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Functions of microRNAs and related small RNAs in plants
Article Abstract:
The number of known microRNAs (miRNAs) and miRNA targets in plants, are lower than in animals but miRNA action seems to be wide, including aspects of development, adaptive responses to stresses and the regulation of miRNA pathway itself. Large scale cloning efforts are initiated to identify the complete range of small RNAs in plants, and deciphering the complete range of small RNA targets as well as their roles will be one of the future challenges in this rapidly growing field.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Canalization of development by microRNAs
Article Abstract:
Canalization is the process of formation of virtual 'canals' in which developmental programs flow and new studies into microRNA (miRNA) function show that miRNAs act as key players in canalizing genetic programs. It is suggested that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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