Vitamin A supplementation and child mortality: a meta-analysis
Article Abstract:
Supplementation of diet with vitamin A may decrease the number of deaths among children with measles, whether hospitalized or still in the community. Vitamin A deficiency is common among children in many developing countries. A survey of the medical literature found that supplementation with vitamin A decreased the number of deaths among children hospitalized with measles. Supplementation with vitamin A had a protective effect against death from a respiratory infections among these children. The protective effect of vitamin A was greater in children under two years old than in older children, and in higher-risk areas. Supplementation with vitamin A also decreased the number of deaths among children in the community. The protective effect of Vitamin A was slightly higher in younger children than in older children in the community. Vitamin A should be given to all children suffering from measles regardless of whether they have a vitamin A deficiency.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1993
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A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts: treatments for myocardial infarction
Article Abstract:
Cumulative meta-analysis is a statistical technique which helps to identify the year when the combined results of medical research in multiple randomized control trials (RCT) reach a level of statistical significance. When results reach this level, the technique shows whether one treatment is better than another and allows researchers to assess the impact of new RCTs on current treatment recommendations. Because of the lag between the publication of research results and these results reaching practicing physicians and opinion leaders, there are many differences between treatment recommendations from new RCTs and treatment recommended by physicians and medical experts. Overcoming this lag is one of the goals of the Agency for Health Care Policy and Research, part of the Heart, Cancer and Stroke program established by Congress in 1965.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
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Cumulative meta-analysis of therapeutic trials for myocardial infarction
Article Abstract:
Cumulative meta-analysis may be an effective method for comparing the findings of clinical trials evaluating the use of drugs or medical procedures. Cumulative meta-analysis was used to analyze 33 clinical trials between 1959 and 1988 that evaluated the use of intravenous streptokinase to break up blood clots in heart attack patients. After eight clinical trials using 2,432 patients, there was a significant decrease in the number of deaths from a heart attack among patients treated streptokinase. No significant increase in effectiveness was seen in the next 25 clinical trials that examined the use of streptokinase in 34,542 patients. Cumulative meta-analysis was also used to compare clinical trials that evaluated the use of fourteen other drugs used to treat heart attack patients.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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