Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine
Article Abstract:
The results from the neurogenic inflammation and c-fos expression studies have confirmed the neural transmission blockade mechanism of both sumatriptan and ergot alkaloids in relieving vascular headaches. The mitigating mechanism involves the mediation of a prejunctional 5-hydroxytryptamine-like receptor which constricts coronary artery and intra-cranial vascular smooth muscle. Furthermore, the neuronal mechanism of sumatriptan and ergot alkaloids makes them viable medications for migraines complicating meningeal inflammation.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
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5-HT1-like receptors: six down and still counting
Article Abstract:
Pharmacological studies reveal that the application of molecular cloning techniques yielded a diverse set of neurotransmitter receptors which exhibit the capacity for exploitation in the area of selective drug development. These findings are best illustrated by the cloning of 5-HT (serotonin) receptors. Other studies validate these results but indicate biphasic curve solutions to displacement studies.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1993
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