Neurotrophins and depression

Article Abstract:

The stimulation of monoamine-containing neurone growth and function through exogenous delivery of brain-derived neurotrophic factors or neurotrophin-3 from antidepressants has been studied. The treatment of depression has made significant progress with the discovery of drugs that prevent the inactivation of the neurotransmitters 5-HT and noradrenaline. Monoamine oxidase inhibitors slows the enzymatic degradation of these neurotransmitters. Monoamine reuptake blockers stop the normal recapture of the neurotransmitters by transporting them back into the presynaptic nerver terminal.

Drug therapy, Depression, Mental, Depression (Mood disorder), Antidepressants

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Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

Article Abstract:

Gamma-hydroxybutyric acid (GHB) is a substance that can be found in the brain cells of mammals. Synthesized from GABA, it is believed to act as a central neuromodulator and has been employed as an anaesthetic, as a treatment for sleep disorders and as a therapeutic agent for managing opioid and alcohol dependence. GHB intake, however, can lead to severe intoxication and repeated use can induce dependence in people with a history of addiction. Other effects of GHB are reported, including its effect on neurotransmitter systems and its interaction with GABA neurotransmission.

Mammals, Neurology, Neurotransmitters, GABA

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Regulation of brain neurotrophin expression by physiological activity

Article Abstract:

Some experts believe gene expression contributes to the changes caused by repetitive brain seizures in the anatomy and excitability of brain networks. New research suggests the existence of previously unknown mechanisms whereby patterns of physiological activity associated with behavior promote survival and plasticity in brain systems. Activity-dependent changes in neurotropin expression are likely to play a major role in seizure-induced changes in the brain.

Neuroplasticity

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