Pharmacological inhibition of restenosis: learning from experience

Article Abstract:

Percutaneous transluminal coronary angioplasty can treat occlusive coronary artery disease. However, this technique can result in restenosis in 25-50% of patients within six months following the procedure. Studies show that inhibition of vascular smooth muscle cell proliferation may not be the best way to prevent lumen narrowing. In vivo studies of lumen area and wall thickness as well as the functional parameters of the vessel are suggested to develop new efficacious therapies for restenosis.

Physiological aspects, Cardiovascular system, Circulatory system, Transluminal angioplasty, Balloon angioplasty, Arteries, Arterial stenosis

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PET: a symposium highlighting its clinical and pharmacological potential

Article Abstract:

The EC and the European Federation for Pharmaceutical Sciences co-sponsored a symposium on the potential of positron emission tomography (PET) in improving drug development and evaluation. PET's effectivity in neurological, cardiological and oncological applications was discussed. Some sectors argued that regulatory bodies would be intimidated by the extra costs involved in PET usage, but most of the participants agreed that PET will play a significant role in drug development.

Usage, PET imaging, Positron emission tomography

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mRNA differential display: application in the discovery of novel pharmacological targets

Article Abstract:

Discovery of differential expressed genes is important in the discovery of new molecular targets for pharmacological manipulation and drug development. Polymerase chain reaction (PCR)-based methods to identify differentially expressed genes include mRNA differential display, RNA fingerprinting and arbitrarily primed PCR. mRNA differential display is particularly an essential additional tool with applications in both in vitro and in vivo test systems.

Methods, Gene expression, Genetic research

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