Dopamine receptor interactions: some implications for the treatment of Parkinson's disease

Article Abstract:

L-DOPA has longbeen known to relieve the symptoms of Parkinson's disease and was believed to have the striatum as the its site of action. However, evidence suggests that L-DOPA's conversion to dopamine and its activation of dopamine receptors also occur in other brain areas, particularly in the substantia nigra. Studies suggest that the activity of D1 receptors in the substantia nigra are related to the synergistic effects of D1 and D2 receptor agonists. Mechanisms underlying the role of dopaminergic drugs, specifically D1 and D2 agonists, on the movement of 6-OHDA-lesioned rats are believed to have numerous implicationsfor the treatment of Parkinson's disease.

Research, Drug therapy, Parkinson's disease, Parkinson disease, Dopamine, Dopamine agonists, Dopa, L-dopa

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When cytokines get on your nerves: cytokine networks and CNS pathologies

Article Abstract:

Cytokine actions in acute and chronic central nervous system (CNS) pathologies allowed scientists of various backgrounds a better understanding of diseases during the meeting called 'Cytokines in the Brain: Neuropathological Aspects' in St.-Jean-de-Luz, France, on Apr. 26-28, 1996. Scientists from the fields of immunology, physiology, biochemistry, pharmacology and neurosurgery discussed a number of significant issues on cytokine actions in several CNS pathologies. These included the possibility of inflammatory or immune responses developing in the brain and the presence of antigen presenting cells in the brain.

Conferences, meetings and seminars, Central nervous system, Cytokines

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A tortuous and viscous route to understanding diffusion in the brain

Article Abstract:

A recent review made by Nicholson and Sykova has elucidated the mechanism of molecular diffusion in the brain and the influence of pathologic and physiologic processes on diffusion. Of particular interest is the concept of tortuosity which is affected by cellular obstacles and viscous interactions between the diffusing particle and extracellular macromolecules. Calculations reveal that the tortuosity is substantially increased by an increase in viscosity.

Biological transport, Diffusion, Diffusion (Physics)

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