Gene targeting and behaviour: a genetic problem requires a genetic solution
Article Abstract:
R. Gerlai stressed that the interpretation of behavioral phenotypes in mice generated by gene targeting may be clouded by problems related to the genetic background of the parental mouse strains. To determine whether the behavioral alteration is due to the targeted mutation or due to genes linked to the mutation, F2 animals from heterozygous mutant F1 inter-breedings should be compared with the offspring of wild-type F1 inter-breedings.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1996
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Article Abstract:
Several neuroscientists have been debating the utility of gene targeting in analyzing mammalian behavior. Gene targeting allows precise manipulation of single genes and allows the analysis of phenotypical effects of genes. Gene-targeting techniques can rely on the plethora of unspecified consequences to understand genetic control of brain function. This technique is essential in detailed investigations of brain biology and behavior.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Reverse piedpiperase: is the knockout mouse leading neuroscientists to a watery end?
Article Abstract:
There has been a debate on the utility of the null mutation, or the single-gene knockout, as a new molecular-genetic technique for examining the role of particular proteins in brain function. However, until it can be proven that the null mutation of a single gene has no effect on the expression of any other gene, knockout manipulation should not be considered as a method to reveal information about the function of a single protein.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
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