Mixed signals in Alzheimer's disease

Article Abstract:

Alzheimer's disease (AD) is a neurodegenerative disorder marked by loss of memory and learning with a complex etiology. A recent study indicates the possibility that Go-mediated nucleosomal DNA fragmentation is present in the brains of mice. The establishment of primary neuronal cultures from these transgenic mice is essential for the biochemical and pharmacological analysis of the new intrinsic signaling function of amyloid precursor protein and for the determination of the possible perturbance of this signaling pathway by the V642 familial AD mutations.

Analysis, Genetic aspects, Alzheimer's disease, Mutation (Biology), Mutation

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Vectors, routes and maps: new discoveries about navigation in insects

Article Abstract:

Two experiments on insect navigation indicate that insects do not possess a cognitive map to move along new routes. The first experiment revealed that desert ants navigate by associating walking vectors and compass information or landmark memories. The second experiment shows that honeybees can integrate vector information from two routes to navigate a new route without using a cognitive map. These findings suggest that the cognitive-map concept is no longer applicable for understanding the spatial behavior of animals.

Behavior, Neurobiology, Insects, Honeybee, Ants, Geographical perception, Cognition in animals, Animal cognition, Animal navigation

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Adenovirus vectors enter the brain

Article Abstract:

Four separate studies using replication-defective adenovirus vectors in transfering genes to the brain could have important implications in the solution of neurobiological problems. The studies varied in that they targetted different areas of the brain. This new technique should be compared with other gene-transfer methods and further understanding of the pattern of gene expression is needed.

Methods, Reports, Gene therapy, Brain research, Genetic vectors, Adenoviruses

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