Beta-catenin as oncogene: the smoking gun
Article Abstract:
Three recent studies have identified Beta-catenin as a cause of colon cancer that in concert with other agents. Beta-catenin's interaction with adenomatous polyposis coli (APC) and DNA binding proteins of the T cell factor-lymphoid enhancer factor (Tcf-Lef) family are described.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
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Tumor suppression and transcription elongation: the dire consequences of changing partners
Article Abstract:
Research indicates that elongation may be more important than the initiation of transcription in regulating gene expression, cell growth and neoplasm. Three research efforts that demonstrate the importance of transcriptional elongation are discussed.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1995
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Regulating cell proliferation: as easy as APC
Article Abstract:
One recent study located the tumor suppressor APC in the WINGLESS signal- transduction pathway of mice and WNG in drosophila, while another indicated the tumor suppressor Drosophila discs large as a target of APC.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1996
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- Abstracts: Just the Facts of Chromatin Transcription. DNA repair and transcription: the helicase connection. Mechanisms of gene activation
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