Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y
Article Abstract:
Early researchers of transplant rejection identified a series of antigens appropriately dubbed histocompatibility antigens, meaning compatible tissue antigens. When individuals are mismatched for these antigens, rejection of transplanted tissue is likely. However, it was found that when mice were completely matched for the so-called major histocompatibility antigens, grafted tissue could still be rejected, implying the existence of minor histocompatibility antigens as well. One particularly interesting minor antigen is H-Y, which occurs in males and can cause rejection of male tissue transplanted into female recipients. H-Y is so far the only minor histocompatibility antigen which has been identified in both mice and humans. The minor histocompatibility antigens are presented to T cells by class I molecules of the major histocompatibility complex. While it is clear that the processing of viral antigens and their presentation to T cells is an important aspect of immunity against virus infection, it is less clear how the processing and presentation of these minor histocompatibility antigens takes place. Researchers have now investigated some of the molecular properties which are common to several minor histocompatibility antigens, including H-Y, H-4, and beta-galactosidase. Although the minor histocompatibility antigens are primarily of academic interest, understanding the immune response to these antigens will shed light on related immune responses to various parasitic, bacterial, viral, and tumor antigens. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1990
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Ethical and policy issues of human cloning
Article Abstract:
The National Bioethics Advisory Commission report on human cloning concluded that ii is morally unacceptable to attempt to use somatic cell nuclear transfer cloning to make a child. It recommended legislation prohibiting an attempt and urged further deliberation and education on cloning issues.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
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