Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product
Article Abstract:
One effect of a particular gene (the tat gene) that is part of the human immunodeficiency virus-1 (HIV-1) is to ensure the replication of the virus, but the way in which this occurs is not understood. A factor that may be important is a protein known as p68 kinase, which, when activated, can result in reduced protein synthesis. This means that virus particles will not replicate or will replicate less. p68 levels are increased by interferon and this may be one of the ways interferon works to combat viruses, which are dependent on protein synthesis. But viruses have evolved complicated strategies for survival, and it is possible that the HIV-1 virus can circumvent the p68 system. Laboratory experiments were designed to determine whether HIV-1 virus can actually regulate the amount of p68 kinase. HIV-1 infection of cells grown in tissue culture did lead to a decrease in the amount of p68 kinase these cells contained. Results from additional studies suggested that the tat gene is responsible for this effect. Reduction of p68 kinase could be a way the HIV-1 virus begins to replicate. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1990
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Protein prenylation, et cetera: signal transduction in two dimensions
Article Abstract:
Two recent studies gained insight into protein prenylation, in which a farnesyl group is attached to a protein for modification purposes. One described the structure of an enzyme that links the group to proteins. The other identified two yeast genes responsible for a later modification step.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
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One molecule orchestrates amoebae
Article Abstract:
Researchers have identified an enzyme called PKA that controls the organizational behavior of Dictyostelium cells. PKA modulates the internal cyclic adenosine monophosphate responses of the amoeba.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
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