Design and synthesis of new classes of heterocyclic C-glycoconjugates and carbon-linked sugar and heterocyclic amino acids by asymmetric multicomponent reactions (AMCRs)
Article Abstract:
Four classes of new bioactive molecules were designed and synthesized by asymmetric multi-component reactions in some cases with the cooperation of polymer-assisted solution-phases (PASP) technique. These comprise C-glycosyl dihydropyrimidines and dihydropyridines through Biginelli and Hantzsch cyclocondensations, C-glocosyl [beta]-amino acids through Mannich-and Reformatsky-type reactions, C-glycosyl [beta]-lactams through Staudinger reaction, and heterocyclic [alpha]-amino acids, glycine and alanine, through the Biginelli and Hantzsch reactions.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Fluorescent hybridization probes for sensitive and selective DNA and RNA detection
Article Abstract:
Different approaches are described for designing fluorescent hybridization sensors for sensitive and selective DNA and RNA detection. These sensors have served as switches in emission upon binding to target biomolecules and have allowed for ratiometric fluorescence detection of polynucleotides (PNs) by visualization of the probes when bound to a target PN.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Efficient total synthesis of novel bioactive microbial metabolites
Article Abstract:
The article discusses a new approach for the isolation and total synthesis of naturally occurring bioactive microbial metabolites that can be further used for the development of effective medicines. The pyripyropenes, arisugacins, macrosphelids and neoxaline are the recently developed and most effective microbial metabolites under discussion.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: PM-10 high-volume collection and quantitation of semi- and nonvolatile phenols, methoxylated phenols, alkanes, and polycyclic aromatic hydrocarbons from winter urban air and their relationship to wood smoke emissions
- Abstracts: New insights into the diversity and function of neuronal immunoglobulin superfamily molecules. Color vision
- Abstracts: Synthesis and properties of cyclopropane-derived peptidomimetics. Photophysics and photochemistry of pterins in aqueous solution
- Abstracts: Voice networks: The human voice as a creative medium for musical collaboration. Rorschach audio: ghost voices and perceptual creativity
- Abstracts: Mechanical properties of aircraft materials subjected to long periods of service usage. Analysis of shadow mask tension subjected to thermal and mechanical loads