Human neurodegenerative disease modeling using Drosophila
Article Abstract:
The role of genes associated with human neurodegenerative diseases in the model organism Drosophila is discussed and studied. They include diseases like Parkinson's disease, polyglutamine diseases, Alzheimer's disease, and tau-associated pathologies.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2003
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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
Article Abstract:
The experimental studies aimed at identification and characterization of the neurotoxic protein aggregates are reviewed and focused. Evidence strongly suggests that protein aggregation is neurotoxic and not a product of cell death.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2003
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Copper and iron disorders of the brain
Article Abstract:
The article studies the genetic disorders affecting the copper and iron homeostasis of the human brain. Copper has an essential role in pathogenesis and mental health whereas deficiency of iron leads to neurodegeneration.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2007
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