New intracellular targets for therapeutic drug design

Article Abstract:

Greater understanding of cellular biology has led to new techniques for developing therapeutic drugs. Instead of testing naturally occurring compounds for pharmacological effect, researchers can use the understanding of cellular signaling mechanisms to design drug molecule structures that can modify or inhibit such mechanisms.

Innovations, Cytochemistry, Pharmaceutical research, Drug receptors

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Calcium sparks in vascular smooth muscle: relaxation regulators

Article Abstract:

Researchers have found indications of local increases in Ca2 in a single smooth muscle cell that are believed to be responsible for initiating spontaneous transient outward currents (STOCs). The highly localized and brief Ca2 increases likely facilitate the vasodilatation of small cerebral arteries.

Calcium in the body, Calcium (Nutrient), Blood vessels, Smooth muscle, Vasodilation

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A docking receptor for HDL cholesterol Esters

Article Abstract:

Researchers have identified SR-BI as a receptor for HDL that mediates the selective way that HDL delivers its cholesterol esters to cells. In mice, SR-BI is expresses almost exclusively in tissues in which selective uptake of HDL cholesterol has been demonstrated in vivo.

Discovery and exploration, High density lipoproteins, Cell receptors, High density lipoprotein receptors

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