Small molecule oxidation products trigger disease-associated protein misfolding
Article Abstract:
The two common neurodegenerative disorders, the formation of alpha-synucleinopathies, like in Parkinson's disease and dementia with Lewy bodies and AlzheimerEs disease are aggravated by oxidative stress and inflammation and are related with neurotoxic deposition of misassembled alpha-synuclein and amyloid-[beta] (A[beta]) peptides. The mechanism of small molecule oxidation product-mediated protein misassembly, which increases the misassembly of both Abeta and alpha-synuclein, is investigated.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
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Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amloidoses
Article Abstract:
Small molecule-mediated protein stabilization inside or outside of the cell is a promising strategy to treat misfolding/misassembly diseases. The focus on the transthyretin (TTR) ambloidoses and demonstrate that preferential ligand binding to and stabilization of the native state over the dissociative transition state raises the kinetic barrier preventing TTR amyloid fibril formation.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2005
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Rapid photochemical cross-linking-A new tool for studies of metastable, amyloidogenic protein assemblies
Article Abstract:
Amyloidoses comprise a class of diseases characterized pathologically by the presence of deposits of fibular, aberrantly folded proteins, known as amyloids. The application of the method Photoinduced Cross-Linking of Unmodified Proteins (PICUP) is described to study amyloid beta-protein.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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