Comparative analysis of PAH:DNA adducts formed in lung of mice exposed to neat tar and soils contaminated with coal tar
Article Abstract:
A two-year study feeds mice with coal tar to determine the effect of the contaminants benzo(b)fluoranthene, benzo(a)pyrene, and benzo(c)fluorene. Lung tissues and tumors in the mice are evaluated for contaminants, and the results are graphed.
Publication Name: Environmental Science & Technology
Subject: Science and technology
ISSN: 0013-936X
Year: 2001
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Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils
Article Abstract:
Polynuclear aromatic hydrocarbons (PAH) bioavailability has been found to be greatly reduced by tar contamination from manufactured gas plants (MGP). Mice were used as subjects and results show that MGP tar resulted in 9%-75% PAH systemic bioavailability in urine and nondetectable to 76% PAH systemic bioavailability in chemical:DNA adduct formation. The results show promise in reduced PAH bioavailability when soil ingested is contaminated with MGP tar.
Publication Name: Environmental Science & Technology
Subject: Science and technology
ISSN: 0013-936X
Year: 1998
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Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils
Article Abstract:
Polynuclear aromatic hydrocarbons (PAH) bioavailability has been found to be greatly reduced by tar contamination from manufactured gas plants (MGP). Mice were used as subjects and results show that MGP tar resulted in 9%-75% PAH systemic bioavailability in urine and nondetectable to 76% PAH systematic bioavailability in chemical: DNA adduct formation. The results show promise in reduced PAH bioavailability when soil ingested is contaminated with MGP tar. The experimental processes utilized in this study can also be used to evaluate systemic bioavailability of PAH and gastrointestinal absorption of soil contaminated with complex organic mixtures.
Publication Name: Environmental Science & Technology
Subject: Science and technology
ISSN: 0013-936X
Year: 1998
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