Effect of rhEPO administration on serum levels of sTfR and cycling performance

Article Abstract:

An increase in the blood level of soluble transferrin receptor in athletes may be a sign that they are abusing recombinant erythropoietin (rhEPO). rhEPO is used to treat anemia but its potential for abuse led the International Olympic Committee to ban the peptide.

Identification and classification, Drugs and athletes, Erythropoietin, Recombinant, Recombinant erythropoietin

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Increased neuroendocrine response to a repeated bout of endurance exercise

Article Abstract:

This article examines the endocrine response in a second bout of high-intensity endurance exercise performed on the same day as a similar exercise. The results show that neuroendocrine response is more pronounced in the second bout than in the first, and involves both the hypothalamo-pituitary-adrenal axes and the sympatho-adrenal system.

Norway, Analysis, Hormones, Catecholamines

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Serum sTfR levels may indicate charge profiling of urinary r-hEPO in doping control

Article Abstract:

Change in the charge pattern of urinary human erythropoietin (u-hEPO) of well-trained athletes before, during and after controlled administration of recombinant human EPO (r-hEPO) is demonstrated so that it could be related to altered levels of hemoglobin (Hb) hematocrit (Hct), soluble transferrin receptor (sTfR0) and maximal oxygen uptake. A significant correlation was found between the relative amount of basic u-hEPO variants and the relative levels of sTfR.

Science & research, Health aspects, Research, Erythropoietin, Hematocrit

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