A closer look at E2F
Article Abstract:
The gene of E2F, a cellular DNA-binding protein that enables adenoviruses to use the cells' transcription and replication mechanisms, has been cloned for the first time. Since 1988 scientists have been examining E2F and the closely related E21 to gain a better understanding of transcriptional regulation. Now two groups, one led by K. Helin and the other by W. Kaelin, report the cloning of the complementary DNA encoding E2F. This cloning was achieved due to retinoblastoma protein's ability to interact with E2F.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
Article Abstract:
Myc and Ras activities are known to play a key role in permitting cell-cycle progression. Indeed, inhibition of Ras activity has been found to block the normal growth-dependent activation of G1 cyclin-dependent kinase (CDK). It also leads to cell-cycle arrest in G1. It appears that Ras is needed for the generation of G1 CDK activity. Ras and Myc working together in the G1 CDK/Rb/E2F pathway are particularly important for activation of cyclin E-dependent kinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Specific binding of the transcription factor sigma-54 to promoter DNA
Article Abstract:
Sigma-54, a specialized transcription factor, is solely responsible for promoter DNA binding that allows RNA polymerase holoenzyme to link with promoter DNA. This contact is essential to transcription and the assembly of specific complexes on DNA. These complexes are produced by the DNA-binding properties of sigma-54. This strategy for producing transcription resembles what has been suggested for eukaryotic RNA polymerase II systems.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Caribou calf production and seasonal range quality during a population decline. Estimation of brood and nest survival: comparative methods in the presence of heterogeneity
- Abstracts: Caribou calf production and seasonal range quality during a population decline. part 2 Habitat and diet selection by muskoxen and reindeer in western Alaska
- Abstracts: Sequence analysis and acute pathogenicity of molecularly cloned SIV. Interference with the assembly of a virus-host transcription complex by peptide competition
- Abstracts: Lost numbers game. Alberts emphasizes education as nominee to head NAS. NSF falls short on shortage
- Abstracts: Worlds in common through NF-kappa-B. Hox9 genes and vertebrate limb specification. A tool for transgenesis