A cytokine-responsive I-kappa-B kinase that activates the transcription factor NF-kappa-B
Article Abstract:
Protein kinase activity activated by tumour-necrosis factor (TNF) and phosphorylates I-kappa-B-alpha at S32/36 has been identified in extracts of TNF-treated HeLa cells. The substrate specificity and kinetics of activation were well aligned with those of phosphorylation in living cells. It was possible to determine a partial peptide sequence for one of the components of this activity, a protein kinase with associated I-kappa-B activity quickly stimulated by proinflammatory cytokines. This protein kinase, IKK-alpha, is vital for NF-kappa-B activation in the presence of proinflammatory cytokines.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Three distinct signalling responses by murine fibroblasts to genotoxic stress
Article Abstract:
All genotoxic stresses activates the p53 signalling pathway in murine fibroblasts, while Jun kinases (JNK) and c-Abl are stimulated only by specific DNA-damaging agents. Except for ultraviolet light, all stimuli activate c-Abl. The activation of c-Abl occurs in the S-phase of the cell cycle and fails to affect cell proliferation. Only ultraviolet light and methyl methanesulphonate activate JNK. The activation of JNK by the alkylating agent is normal in c-Abl-null cells and reduced in the c-Src-null cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Mammalian MAP kinase signalling cascades
Article Abstract:
Research is presented concerning the influence of mitogen-activated kinases in the regulation of the physiological processes of cells. The signalling cascades which control cell proliferation, gene expression and cell death are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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