A genome-wide search for quantitative trait loci underlying asthma
Article Abstract:
A genome-wide search for linkage to one qualitative and four quantitative traits associated with allergic (atopic) asthma shows that there are six potential linkages that complicate the genetic predisposition to asthma. Five of these are linked to quantitative traits, and Monte Carlo simulations reveal 1.6 false-positive linkages at this level. Three new loci provide evidence of linkage to a second type of families that show maternal effects and pleiotropy of linked phenotypes. These results are in addition to an earlier established linkage to chromosome 11q13.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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From DNA sequence to biological function
Article Abstract:
Analysis of the genome sequence of the simple eukaryote model Saccharomyces cerevisiae will be helpful in the analysis of larger genomes and the prediction of gene function. The activity of genes can be determined by studying the phenotype caused by mutant genes, the similarity of an encoded protein to a protein of known activity, and the contribution of enzymes to the metabolic pathway. Newly discovered human genes and those involved in human heritable diseases are studied on the basis of the model yeast genome data.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Fugu genome is not a good mammalian model
Article Abstract:
The genomic repertoire of the six Surfeit genes, the ASS gene and EST00098 are vastly different in Fugu and mammals. This was gleaned from a study of the unique spatial organization and clustering of the mammalian Surfeit genes which comprise the tightest mammalian gene cluster known to date. Results indicate that local DNA rearrangements have been common in one or both lineages which gave rise to Fugu and mammals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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