A license for duplication
Article Abstract:
Genome stability in animal cells necessitates strict control over the numbers of the organelles called centrosomes, which organize the construction and maintenance of the microtubule cytoskeleton that confers shape and polarity on the cell. An attractive 'licensing model' that explains how Centro some duplication is restricted to just once per cell cycle is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Cell cycle regulation of central spindle assembly
Article Abstract:
A regulatory mechanism that controls the timing of the cell cycle regulation of the central spindle assembly is described. It is seen that the central spindle assembly occurs at the appropriate time in the cell cycle and maintains genomic stability due to the phosphoregulation of the motor domain of MKLP1 kinesin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Proteomic characterization of the human centrome by protein correlation profiling
Article Abstract:
A mass-spectrometry-based protemic analysis of human centrosomes in the interphase of the cell cycle by profiling proteins quantitatively. True centrosomal proteins were revealed by both correlation with already known centrosomal proteins and in vivo localization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: an ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation. Cephalopod Hox genes and the origin of morphological novelties
- Abstracts: A critical window for cooperation and competition among developing retinotectal synapses. Clocking the birth of neurons
- Abstracts: Deregulation of a Ca2+/ calmodulin-dependent kinase leads to spontaneous nodule development. Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases
- Abstracts: Targeted dehydration of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Functional interaction of phytochrome B and cryptochrome 2