A march of genetic maps
Article Abstract:
The completion of comprehensive genetic maps of man and of the mouse in two separate studies represents significant progress in the Human Genome Project. The creation of genetic maps is one of the three main scientific goals of the project, the other two being the development of physical maps and the determination of the complete sequence of human DNA. The human genetic map completed by Jean Weissenbach and colleagues is made up entirely of markers known as microsatellites. The mouse genetic map produced by Eric Lander, Bill Dietrich and colleagues is also comprised of microsatellite markers but is based on a cross between two strains of mice instead of natural families.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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More from the modellers
Article Abstract:
A new mouse model for cystic fibrosis (CF) has been developed in the UK by David Porteous and colleagues using embryonic stem cell techniques. This mouse model should help with efforts to investigate CF, an often fatal hereditary disease. Moreover, the British murine CF model is different from an earlier model produced by researchers at the University of North Carolina (UNC). For instance, the British mice showed no overt CF symptoms while the UNC mice did. Further research on why these differences exist may illuminate the pathophysiology of CF.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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A welcome animal model
Article Abstract:
A mouse model has been devised for cystic fibrosis (CF) that should greatly aid research on the pathophysiology of this common and sometimes fatal autosomal recessive disease. Although the CF transmembrane conductance regulator gene has been known for some time to be involved in the development of CF, the lack of an animal model has impeded further progress. Now two research teams, one led by J.N. Snouwaert and the other by L.L. Clarke, have used homologous recombination to produce a mouse model whose CF symptoms parallel human CF.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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