SNAP receptors implicated in vesicle targeting and fusion
Article Abstract:
N-ethylmaleimide-sensitive fusion protein (NSF) is a membrane fusion protein which interacts with soluble NSF attachment proteins (SNAPs) during vesicle fusion. Since SNAPs bind to specific sites in membranes,an investigation was conducted to isolate and characterize SNAP receptors. Crude membrane fraction analysis identifed syntaxin, synaptobrevin and a hydrophilic SNAP-25 as SNAP receptors. It is proposed that these SNAP receptorscomprise part of a family of compartment-specific membrane proteins which function in the formation of correct vesicle-membrane attachments during fusion.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
A possible docking and fusion particle for synaptic transmission
Article Abstract:
The soluble N-ethylmaleimide-sensitive fusion (NSF) protein, alpha-soluble NSF attachment protein (SNAP) and beta-SNAP assemble to form a docking and fusion complex for synaptic transmission. Beta-SNAP binds to synaptotagmin and recruits NSF but alpha-SNAP is unable to do so. The complex probably associates the process of membrane fusion to the entry of calcium by attaching the fusion protein, beta-SNAP, to the calcium sensor, synaptotagmin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: NASA ponders "faster, cheaper" way to send scientific mission to Pluto. NASA pays the price of its dash for Mars
- Abstracts: Transport, docking and exocytosis of single secretory granules in live chromaffin cells. Transport, capture and exocytosis of single synaptic vesicles at active zones
- Abstracts: A mutant of the motor protein kinesin that moves in both directions on microtubules. Self-organization of microtubules and motors
- Abstracts: Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Topological restriction of SNARE-dependent membrane fusion
- Abstracts: Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Synaptotagmin I functions as a calcium regulator of release probability